The PI3K inhibitors pipeline analysis report covers
approximately 37 active drug candidates in different stages of development.
Phosphatidylinositol 3-kinases (PI3K) are lipid kinases that are
involved in cell regulation, including cell survival, proliferation and
differentiation. They act as intermediate molecules in PI3K/AKT/mTOR signaling
pathway by sending chemical messengers from cell surface to cytoplasm. These
signals activate multiple effector kinase pathways, resulting in survival and
growth of normal cells. Phosphatidylinositol 3-kinases is categorized on the
basis of classes as class I, II and III, on the basis of structure of the PI3K,
based on the specificities of the substrate as well as on the basis of lipid
end-product’s nature. Bases on structure, Phosphatidylinositol 3-kinases has
four different forms PI3K alpha, PI3K beta, PI3K gamma and PI3K delta.
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In March 2017, Bayer AG presented clinical results of Phosphoinositide
3-kinase (PI3K)-targeting drug candidate Copanlisib in Phase II CHRONOS-1
trial, evaluating patients with relapsed or refractory indolent non-Hodgkin's
lymphoma (iNHL), trial with NCT ID 01660451. The results across all patient
groups showed an objective response rate (ORR) of 59.2%, with a 12% complete
response (CR) rate and a median duration of response (DOR) of more than 98 weeks,
or 687 days (range 0-687).
The research found that
different companies engaged in manufacturing of PI3K inhibitors are
collaborating. One of the collaborations occurred in November 2016 between
Verastem, Inc. and Infinity Pharmaceuticals, Inc.
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The major players for PI3K inhibitors pipeline include, but are not
limited to, Novartis AG, Genentech, Inc., SignalRX Pharmaceuticals Inc. and
others.
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