Phosphatidylinositol 3-Kinase Inhibitors Pipeline - Clinical Trials & Results, Collaboration and Developments

The PI3K inhibitors pipeline analysis report covers approximately 37 active drug candidates in different stages of development.

Phosphatidylinositol 3-kinases (PI3K) are lipid kinases that are involved in cell regulation, including cell survival, proliferation and differentiation. They act as intermediate molecules in PI3K/AKT/mTOR signaling pathway by sending chemical messengers from cell surface to cytoplasm. These signals activate multiple effector kinase pathways, resulting in survival and growth of normal cells. Phosphatidylinositol 3-kinases is categorized on the basis of classes as class I, II and III, on the basis of structure of the PI3K, based on the specificities of the substrate as well as on the basis of lipid end-product’s nature. Bases on structure, Phosphatidylinositol 3-kinases has four different forms PI3K alpha, PI3K beta, PI3K gamma and PI3K delta.

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In March 2017, Bayer AG presented clinical results of Phosphoinositide 3-kinase (PI3K)-targeting drug candidate Copanlisib in Phase II CHRONOS-1 trial, evaluating patients with relapsed or refractory indolent non-Hodgkin's lymphoma (iNHL), trial with NCT ID 01660451. The results across all patient groups showed an objective response rate (ORR) of 59.2%, with a 12% complete response (CR) rate and a median duration of response (DOR) of more than 98 weeks, or 687 days (range 0-687).

The research found that different companies engaged in manufacturing of PI3K inhibitors are collaborating. One of the collaborations occurred in November 2016 between Verastem, Inc. and Infinity Pharmaceuticals, Inc.

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The major players for PI3K inhibitors pipeline include, but are not limited to, Novartis AG, Genentech, Inc., SignalRX Pharmaceuticals Inc. and others.

Innovating Technologies Offer Development of Novel Therapies

The study analysed that the Synovial sarcoma pipeline comprises of 22 drug candidates in different stages of development. Synovial sarcoma is rare type of cancer and approximately one to three people in one million people are diagnosed with synovial sarcoma every year, globally. The disease occurs frequently in young adults; however, the disease can affect a person at any age. Synovial sarcoma is more common in males, and the male to female ratio of the disease stands at 12 males for every 10 females. Various new therapies and advanced technologies are driving the growth of Synovial sarcoma pipeline.

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Many technologies such as REOLYSIN technology, ZVex and GLAAS technology, Laser Micro-beam Microdissection are being developed that can bring the innovative treatment, which can control the progression of Synovial sarcoma.  ZVex and GLAAS are complementary discovery platforms designed to activate and expand the immune system’s natural ability to create tumour-specific cytotoxic T cells (CTLs) in vivo.

The research also found that various companies have collaborated for the development of Synovial sarcoma pipeline. In February 2014, Pfizer Inc. (Pfizer) and Merck & Co., Inc. (Merck) agreed to explore the therapeutic potential of Merck’s investigational anti-PD-1 therapy, MK-3475, in combination with two of the Pfizer’s oncology assets.

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Some of the key players developing drugs for Synovial sarcoma include Takara Bio Inc., Oncolytics Biotech Inc., Accuronix Therapeutics, Inc., Cue Biopharma, Inc. and others.

Post-Traumatic Stress Disorder Therapeutics Pipeline Analysis, 2017 - Clinical Trials & Results, Patent and Other Developments

The study analysed that the PTSD pipeline comprises of 23 drug candidates in different stages of development. PTSD is a neurological disorder that develops in people who have experienced a scary or a dangerous event. PTSD can occur in a person at any age. According to the National Center of PTSD, around seven to eight out of 100 individuals experience PTSD at some point in their lives. Most of the people recover from traumatic situation naturally, but those who continue to experience problems are diagnosed with PTSD. People with PTSD are used to feel frightened even when they are not in a dangerous situation. PTSD generally occurs more often in women than men. Various collaboration between educational institutes, associations, and pharma companies are driving the therapeutic pipeline of PTSD.

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Many patents have been received during the development of drug candidates for the treatment of PTSD. In May 2017, Tonix reported the issuance of patent 9 636 408 by the United States Patent and Trademark Office titled “Eutectic Formulations of Cyclobenzaprine Hydrochloride and Amitriptyline Hydrochloride,” covering the composition and manufacture of its proprietary sublingual formulation of very low dose cyclobenzaprine.

Significant growth in the therapeutic pipeline of PTSD is attributed to increasing collaboration between educational institutes, associations and pharma companies. Funds from the non-profit organizations have also been supporting the pipeline growth of PTSD therapeutics.

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Some of the key players developing drugs for the treatment of PTSD include India Globalization Capital, Inc., Therapade Technologies LLC, Axim Biotechnologies, Inc. and others.

Diabetic Foot Ulcer Therapeutics Pipeline - Clinical Trials & Results, Collaboration and Developments

The study analysed that the diabetic foot ulcer pipeline comprises of approximately 27 drug candidates in different stages of development.

Diabetic foot ulcer is a serious complication of diabetes and can be defined as the ulceration in foot along with neuropathy or peripheral artery disease of the lower limb in diabetic patients. Diabetic foot ulcer is categorized into two types namely; neuropathic foot where neuropathy dominates and neuroischemic foot where occlusive vascular disease is the main factor. Diabetic neuropathy, peripheral artery disease and consequent trauma of the foot are the major risk factors for diabetic foot ulcer. The motor and sensory nerve damage can caus muscle weakness, paresis and atrophy in diabetic patients. Diabetic foot ulcer can be assessed by physical examination of the skin for the vascular, neurological, and musculoskeletal systems. Additionally, this examination also involves the assessment of perception of superficial pain, and temperature. Neuropathic disability score is assessed to evaluate the risk of occurrence of neuropathic ulceration.

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Most of the innovations in technology have been producing novel therapies for the treatment of diabetic foot ulcer. NOx is an advanced wound care technology invented by Edixomed Ltd, that provides the important moist environment, which aids in healing and absorbs wound exudate that generates nitric oxide.

Significant growth in the therapeutic pipeline of diabetic foot ulcer is attributed to increasing collaboration between educational institutes, associations and pharma companies as well as biotech companies. For instance, i March 2016, Microbion Corporation entered into an agreement with Haisco Pharmaceutical Group to develop and commercialize Microbion’s drug candidate for the treatment of chronic wounds in China and related territories.

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Some of the key players developing drugs for the treatment of diabetic foot ulcer include Lakewood Amedex, Inc., Edixomed Ltd., CardioVascular BioTherapeutics Inc. and others.

Candidiasis Therapeutics Pipeline Analysis 2017 - Designation, Collaboration, and Other Developments

The study analyzed that the candidiasis therapeutics pipeline comprises approximately 22 drug candidates in different stages of development.

As per the findings of the research, most of the candidiasis drug candidates are being developed to be administered by oral route.

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Matinas Biopharma Holdings, Inc. is using Cochleate technology platform for the development of their drug candidates. The technology platform is a lipid-crystal nano-particle targeted drug delivery system, that offers a drug delivery solution with differentiating and disruptive features including oral availability, multi-organ protection, enhanced safety and targeted delivery to the site of the infection and inflammation along with the ability to effectively penetrate the tissues.

The research found that various companies received many designations from the U.S. Food and Drug Administration (USFDA) for the development of candidiasis therapeutics pipeline. In May 2016, USFDA granted the orphan drug designation to SCY-078 for the treatment of invasive candida infections, including candidemia.

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Some of the key players developing drugs for the treatment of candidiasis include Seren Pharmaceuticals, Inc., SCYNEXIS, Inc., Matinas Biopharma Holdings, Inc., and others.

Post-Operative Pain Therapeutics Exhibits Emerging Pipeline with 35+ Drug Candidates

The study analyzed that the post-operative pain therapeutics pipeline comprises approximately 39 drug candidates in different stages of development. Post-operative pain is one of the most common problem experienced by a person after any surgery. The intensity of pain can vary from acute to chronic depending upon the time it lasts. It starts when pain receptors activate an electrical signal that travels to the spinal cord. The spinal cord then transmits the signal to the brain. It involves the interaction of various chemicals, known as neurotransmitters, in the body, which together act to produce the sensation of pain in a person.

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Innocoll Holdings plc is using CollaRx technology platform for the development of INL-001 for the treatment of post-operative pain. The CollaRx technology platform produces a lyophilized porous matrix of purified collagen that can be implanted at the time of surgery or applied topically to chronic or acute traumatic wounds. The CollaRx matrices are biodegradable and bio-resorbable. The in vivo release of drugs incorporated into the CollaRx matrix takes place via a combination of dissolution, diffusion and the interactive characteristics of the active drug and the formulation that can be modified to affect controlled release.

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Some of the key players developing drugs for post-operative pain include DURECT Corporation, Elite Pharmaceuticals, Inc., Cara Therapeutics, Inc. and others.

Anti-Aging Market Trends, Size, Share, Growth and Demand Forecast to 2025

According to the study, the global anti-aging market is expected to witness 7.7% CAGR during 2017 – 2025. Technological advancements, increase in volume of anti-aging procedures, growing aging population and increase in disposable income have been driving the global anti-aging market. The market is further expected to gain revenue due to increase in anti-aging awareness campaigns. For instance, EuroMediCom plans to organize the 15^th Aesthetic & Anti-Aging Medicine World Congress from 6^th April to 8^th April, 2017, in Monaco. Furthermore, EuroMediCom is also going to organize the 4^th AMWC Latin America- Aesthetic & Anti-Aging Medicine World Congress from 16^th November to 18^th November, 2017, in Colombia, South America. EuroMediCom promotes future medical sciences, particularly those related to aging and aesthetics.

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As per the findings of research, anti-wrinkle products, which includes dermal fillers and botox, is expected to witness considerable growth during the forecast period, primarily due to high sales of botulinum toxin and increasing appearance consciousness and awareness among women about anti-wrinkle products. Anti-wrinkle products include anti-wrinkle milk, anti-wrinkle moisturizers, anti-wrinkle creams, anti-wrinkle gels and anti-wrinkle serums. Wrinkles are formed due to lack of collagen in the body which makes the skin elastic and firm. The two main types of wrinkles include surface lines and deep furrows. Anti-wrinkle creams, oils and gels reduce fine lines, but deep furrows usually require anti-aging treatments, such as plastic surgery and botox injections. Radiofrequency, laser, anti-cellulite, and microdermabrasion devices are used for the anti-aging treatment such as hair restoration, anti-pigmentation, anti-adult acne treatment, liposuction and breast augmentation.

The anti-aging market has witnessed number of mergers and acquisitions and strategic alliances recently. In January 2017, L'Oréal signed an agreement with Valeant Pharmaceuticals to acquire its the skincare brands including, CeraVe, AcneFree and Ambi for a consideration of $1.3 billion in cash. These products are expected to expand L’Oreal’s Active cosmetics division. In July 2016, Johnson & Johnson acquired Vogue International LLC, a privately-held company focusing on marketing hair care and other personal care products, for an amount of $3.3 billion in cash. The acquisition was expected to strengthen Johnson & Johnson’s consumer segment with hair care and personal care products.

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Some of the other key players in the market include The Proctor & Gamble Company, Beiersdorf AG, Allergan Plc., The Estee Lauder Companies Inc., Nu Skin Enterprises, Inc., Coty Inc., Cynosure, Inc., Lumenis Ltd., Syneron Medical Ltd., Photomedex Inc., Orlane, Personal Microderm and Alma Lasers Ltd.

Sjögren’s Syndrome Therapeutics Exhibit Promising Pipeline with approximately 42 drug candidates

The study analyzed that Sjögren’s syndrome pipeline comprises of approximately 42 drug candidates in different stages of development. Sjögren’s syndrome is a chronic inflammatory disease, which leads to infiltration of lacrimal and salivary glands. It is mostly associated with sicca symptoms, which include dry eyes (xeropthalmia) and dry mouth (xerostomia). It is also associated with other autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. The treatment approaches for this disease mostly include monoclonal antibodies and small molecules, which are being developed to target and reduce the inflammatory mediators. Clinical presentation can vary considerably from relatively mild sicca symptoms, fatigue and arthralgia to severe systemic symptoms such as glomerulonephritis, vasculitis and a host of neurological manifestations.

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The positive results of the drug candidates are speeding up the drug development process for Sjögren’s syndrome. In August 2016, Aldeyra Therapeutics, Inc. presented the positive Phase II results of NS2, a 1% dermatologic cream under Phase II stage of development for Sjögren's syndrome. Six of six (100%) subjects treated with NS2 improved over the course of therapy as assessed by central review, and the improvement was greater than that observed among vehicle-treated patients (p < 0.05).

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Some of the key players developing drugs for Sjögren’s syndrome include Kissei Pharmaceutical Co., Ltd., UCB Group, Bristol-Myers Squibb Company and others.

Herpes simplex virus infections Exhibits Emerging Pipeline with 20 Drug Candidates

The study analysed that the Herpes simplex virusinfections pipeline comprises of 20 drug candidates in different stages of development.

As per the findings of the research, most of the drug candidates are being developed to be administered by oral route.

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Many technologies are being developed that offer promising innovative treatments which can control the progression of Herpes simplex virus infections. The technologies include, but not limited to, Vector based technology platform, AdenoVerse technology platform, Juvari’s technology platform and Nanostat technology platform.

The research found that various companies have collaborated for the development of Herpes simplex virus infections pipeline. In June 2014, PaxVax Inc., entered into a research and development collaboration with the University of California to develop a combination vaccine to prevent genital herpes simplex virus infections.

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Some of the key players developing drugs for the treatment of Herpes virus simplex infections include Maruho Co., Ltd., NanoBio Corporation, Lumavita AG and others.